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Antimalarial Natural Products

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Antimalarial Natural Products

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 117))

  • The original version of this chapter was revised (an incorrect series of formulas in the formula scheme on Page 70 has been updated with the correct formula). The correction to this chapter can be found at https://doi.org/10.1007/978-3-030-89873-1_2

Abstract

Natural products have made a crucial and unique contribution to human health, and this is especially true in the case of malaria, where the natural products quinine and artemisinin and their derivatives and analogues, have saved millions of lives. The need for new drugs to treat malaria is still urgent, since the most dangerous malaria parasite, Plasmodium falciparum, has become resistant to quinine and most of its derivatives and is becoming resistant to artemisinin and its derivatives. This volume begins with a short history of malaria and follows this with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. The volume then covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of other natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. The chapter thus ends by identifying over ten natural products with development potential as clinical antimalarial agents.

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Change history

  • 01 January 2022

    The original version of the book was inadvertently published with an incorrect series of formulas (197-199) in the formula scheme on Page 70 of Chapter 1, which has now been replaced with the correct formula (202). The erratum chapter has been updated with the changes and the correct presentation is given here

Notes

  1. 1.

    Note added in proof: The authors recently became aware of the article, Anft B (1955) “Friedlieb Ferdinand Runge: a forgotten chemist of the nineteenth century”, J Chem Ed 32:566 stating that Runge reported the isolation of quinine, which he called “China base”, in 1819, a year before the French team.

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Authors and Affiliations

  1. Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, USA

    David G. I. Kingston

  2. Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA

    Maria Belen Cassera

Authors
  1. David G. I. Kingston
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  2. Maria Belen Cassera
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Correspondence to David G. I. Kingston .

Editor information

Editors and Affiliations

  1. College of Pharmacy, Ohio State University, Columbus, OH, USA

    A. Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

    Heinz Falk

  3. School of Pharmacy, University of East Anglia, Norwich, UK

    Simon Gibbons

  4. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  5. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China

    Ji-Kai Liu

  6. Department of Pharmaceutical Sciences, University of Vienna, Vienna, Wien, Austria

    Verena M. Dirsch

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Kingston, D.G.I., Cassera, M.B. (2022). Antimalarial Natural Products. In: Kinghorn, A.D., Falk, H., Gibbons, S., Asakawa, Y., Liu, JK., Dirsch, V.M. (eds) Antimalarial Natural Products. Progress in the Chemistry of Organic Natural Products, vol 117. Springer, Cham. https://doi.org/10.1007/978-3-030-89873-1_1

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