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Preparation and characterization of microcapsules loaded with polyphenols-enriched Uncaria tomentosa extract using spray-dryer technique

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Abstract

This work prepared and characterized microcapsule of Uncaria tomentosa (UT) in order to standardize a spray-dryer Uncaria tomentosa extract. The UT bark powder was subjected to extraction by maceration using hydro-ethanol solution. The Uncaria tomentosa extract was used to prepare the spray-dryer microcapsules UT-F1. The UT extract and microcapsules UT-F1 were submitted to chemical and physicochemical characterization tests. The phytochemical tests revealed the presence of alkaloids and phenolic compounds such as catechin. The UT extract and microcapsules UT-F1 showed high content of total phenols (28.48% ± 0.76 and 36.34% ± 0.22), high catechin content (47.95% ± 4.90 and 51.15% ± 4.20) and high antioxidant activity with IC50 values of 5.80 and 5.03 µg cm−3. The SEM, FTIR and TG analysis confirmed the morphology of spherical particles, the microencapsulation of the constituents of the UT extract, low moisture content, as well as stability of the microcapsules UT-F1. The DSC analysis and dissolution tests showed the technological influence of spray-dried starch combined UT extract considered water-poorly soluble resulting in vitro release (52.9%) of polyphenolic compounds from Uncaria tomentosa microcapsules. The combined use of disintegrants with a natural surfactant in the UT microcapsules has improved the release of polyphenols (catechin) from spray-dryer herbal composition reaching an equivalent release of 78.6% of catechin after 240 min. The in vitro release of microcapsules UT-F1 responds depending on the concentration of pharmaceutical excipients considered disintegrating and can easily achieve release greater than 80%. The microcapsules UT-F1 can be used as bulk material for herbal products in pharmaceutical industry.

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Acknowledgements

The authors would like to acknowledge CNPq (The Brazilian National Council for Scientific and Technological Development), CAPES (The Brazilian Coordination for the Personal Improvement of Superior Education) and FAPEAL (Foundation for Sponsoring Research in the State of Alagoas) for the scholarships of the Master's course in Nutrition (PPGNUT) and Pharmaceutical Sciences (PPGCF). The CNPq for financial support (Grant No. 446630/2014-4) according to the financial aid to the researchers 14/2014-Universal/MCT/CNPq and FAPEAL by the financial support (Grant No. 600 30 000431/2017) and scholarships—Connecting academia and business. The authors would also like to thank the GOLD CAFÉS LTDA in the person: Gustavo Antonio Antunes for University-Business partnership during PPG COMPANY—Connecting academia and business.

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Authors and Affiliations

  1. Laboratório de Análises Farmacêuticas e Alimentícias (LAFA), Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências Farmacêuticas (ICF), Universidade Federal de Alagoas (UFAL), Maceió, Alagoas, 57072-970, Brazil

    Ticiano Gomes do Nascimento, Arthur Luy Tavares Ferreira Borges, Lara Mendes de Almeida, Êurica Adélia Nogueira Ribeiro, Fernanda Geny Calheiros Silva & Ana Paula do Nascimento Prata

  2. Laboratório de Tecnologia de Secagem, Programa de Pós-Graduação em Nutrição, Faculdade de Nutrição, Universidade Federal de Alagoas (UFAL), Maceió, Alagoas, 57072-970, Brazil

    Valdemir da Costa Silva, Irinaldo Diniz Basílio-Júnior & Marília Oliveira Fonseca Goulart

  3. Laboratório de Química de Analítica Instrumental, Mestrado Profissional em Tecnologias Ambientais, Departamento de Química (DQ), Instituto Federal de Alagoas (UFAL), Av. do Ferroviário, 530 - Centro, Maceió, Alagoas, 57020-600, Brazil

    Demetrius Peireira Morilla & Johnnatan Duarte de Freitas

  4. Quality Control of Drugs Laboratory (LCQMed), Department of Pharmacy, Federal University of Rio Grande do Norte, Rua General Cordeiro de Farias, S/N, Petrópolis, CEP 59010-180, Natal, RN, Brazil

    Cícero Flávio Soares Aragão

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  1. Ticiano Gomes do Nascimento
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Contributions

TGdN conceived the experiment(s), TGdN, ALTFB, LMdA, FGCS, APdNP, MOFG, CFSA and EANR conducted the experiment(s), TGdN, ALTFB, FGCS, VdCS, DPM, JDdF, IDB-J and LMdA analysed the results. TGdN, ALTFB, MOFG, CFSA, LMdA, IDB-J, and TGdN, ALTFB, MOFG, LMdA, APdNP gathered the literature data. TGdN, ALTFB, DPM, JDdF, FGCS, and VdCS prepared the figures and supplementary materials. All authors reviewed the manuscript.

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Correspondence to Ticiano Gomes do Nascimento.

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do Nascimento, T.G., Borges, A.L.T.F., de Almeida, L.M. et al. Preparation and characterization of microcapsules loaded with polyphenols-enriched Uncaria tomentosa extract using spray-dryer technique. J Therm Anal Calorim 147, 11949–11963 (2022). https://doi.org/10.1007/s10973-022-11428-y

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