Abstract
Pineapple processing industry generates large amounts of by-products (peel, core and crown) with a negative environmental impact. The elimination of these implies high costs for food industries, being their main destination animal feed or composting, thus wasting their great potential value attributed to the rich content of bioactive compounds. In this review, we have focused on the description of the bioactive compounds present in pineapple by-products and on the environment-friendly extraction methodologies used to obtain them (ultrasound-assisted extraction, microwave-assisted extraction, submerged and solid-state fermentation), as well as applications of these compounds in different areas. The use of these by-products is a great alternative to mitigate current environmental problems; in addition, green extraction technologies have the advantage of using few solvents, have shorter extraction times and good yields, so they are suitable for obtaining bioactive compounds (gallic acid, catechin, epicatechin, ferulic acid, among others) present in these by-products, which have a high antioxidant, anti-inflammatory, antifungal, anticancer activity and have very relevant applications. This review article demonstrates the great potential of the bioactive compounds present in the pineapple waste that might be used on drugs or foods for treatment of diseases or improvement of the people health.
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References
Ramli ANM, Aznan TNT, Illias RM (2017) Bromelain: From production to commercialisation. J Sci Food Agric 97(5):1386–1395. https://doi.org/10.1002/jsfa.8122
FAO (2019) FAOSTAT. Food and Agricultural Commodities Production. Food and Agricultural Organization of the United Nations-FAO, Rome
Hikal WM, Mahmoud AA, Said-Al Ahl HAH, Bratovcic A, Tkachenko KG, Kačániová M, Rodriguez RM (2021) Pineapple (Ananas comosus L. Merr.), waste streams, characterisation and valorisation: an overview. Open Ecol J 11(09):610–634. https://doi.org/10.4236/oje.2021.119039
Ferreira EA, Siqueira HE, Boas EVV, Hermes VS, Rios ADO (2016) Bioactive Compounds and Antioxidant Activity of Pineapple Fruit of Different Cultivars. Rev Bras Frutic 38(3). https://doi.org/10.1590/0100-29452016146
Fidrianny I, Virna V, Insanu M (2018) Antioxidant Potential of Different Parts of Bogor Pineapple (Ananas Comosus [L] Merr Var Queen) Cultivated in West Java-Indonesia. Asian J Pharma Clin Res 11(1):129. https://doi.org/10.22159/ajpcr.2018.v11i1.22022
Freitas A, Moldão-Martins M, Costa HS, Albuquerque TG, Valente A, Sanches-Silva A (2015) Effect of UV-C radiation on bioactive compounds of pineapple (Ananas comosus L Merr) by-products. J Sci Food Agri 95(1):44–52. https://doi.org/10.1002/jsfa.6751
Morais DR, Rotta EM, Sargi SC, Bonafe EG, Suzuki RM, Souza NE, Visentainer JV (2017) Proximate composition, mineral contents and fatty acid composition of the different parts and dried peels of tropical fruits cultivated in Brazil. J Brazil Chem Soc 28(2):308–318. https://doi.org/10.5935/0103-5053.20160178
Sznida E (2018) The EU ’ s Path Toward Sustainable Development Goals – Responsible Consumption and Production. SSRN, (November), 1–12. https://doi.org/10.2139/ssrn.3292067
Fava F, Totaro G, Diels L, Reis M, Duarte J, Poggi-varaldo M, Carioca OB (2015) Biowaste biorefinery in Europe: opportunities and research & development needs. New Biotechnol 32(1):100–108. https://doi.org/10.1016/j.nbt.2013.11.003
Banerjee J, Singh R, Vijayaraghavan R, Macfarlane D, Patti AF, Arora A (2017) Bioactives from fruit processing wastes: Green approaches to valuable chemicals. Food Chem 225:10–22. https://doi.org/10.1016/j.foodchem.2016.12.093
Pfaltzgraff LA, Debruyn M, Cooper EC, Budarin V, Clark JH (2013) Food waste biomass: A resource for high-value chemicals. Green Chem 15(2):307–314. https://doi.org/10.1039/c2gc36978h
Misran E, Idris A, Mat Sarip SH, Ya’akob H (2019) Properties of bromelain extract from different parts of the pineapple variety Morris. Biocatal Agric Biotechnol 18:101095. https://doi.org/10.1016/j.bcab.2019.101095
Huang YL, Chow CJ, Fang YJ (2011) Preparation and physicochemical properties of fiber-rich fraction from pineapple peels as a potential ingredient. J Food Drug Anal 19(3)
Ketnawa S, Chaiwut P, Rawdkuen S (2012) Pineapple wastes: A potential source for bromelain extraction. Food Bioprod Process 90(3):385–391. https://doi.org/10.1016/j.fbp.2011.12.006
Choonut A, Saejong M, Sangkharak K (2014) The production of ethanol and hydrogen from pineapple peel by Saccharomyces cerevisiae and Enterobacter aerogenes. Energy Procedia 52:242–249
Rico X, Gullón B, Alonso JL, Yáñez R (2020) Recovery of high value-added compounds from pineapple, melon, watermelon and pumpkin processing by-products : An overview. Food Res Int 132:109086. https://doi.org/10.1016/j.foodres.2020.109086
Díaz-Vela J, Totosaus A, Cruz-Guerrero A, Pérez-Chabela ML (2013) In vitro evaluation of the fermentation of added-value agroindustrial by-products: Cactus pear (Opuntia ficus-indica L) peel and pineapple (Ananas comosus) peel as functional ingredients. Int J Food Sci Technol 48(7):1460–1467
Li T, Shen P, Liu W, Liu C, Liang R, Yan N, Chen J (2014) Major Polyphenolics in Pineapple Peels and their Antioxidant Interactions, 2912. https://doi.org/10.1080/10942912.2012.732168
Upadhyay A, Lama JP, Tawata S (2010) Utilization of Pineapple Waste: A Review. J Food Sci Technol Nepal 6:10–18. https://doi.org/10.3126/jfstn.v6i0.8255
Gullón B, Gullón P, Eibes G, Cara C, De Torres A, López-Linares JC, Castro E (2018) Valorisation of olive agro-industrial by-products as a source of bioactive compounds. Sci Total Environ 645(533–542):10
Pardo M, Cassellis R, Escobedo R, Garcia E (2014) Chemical characterisation of the Industrial residues of the pineapple (Ananas comosus). J Agri Chem Environ 3(2B):53–56
Roda A, de Faveri DM, Dordoni R, Lambri M (2014) Vinegar production from pineapple wastes –preliminary saccharification trials. Chemical Engineering Transactions 37:607–612. https://doi.org/10.3303/CET1437102
Romelle F, Ashwini R, Manohar R (2016) Chemical composition of some selected fruit peels. Eur J Food Sci Technol 4:12–21
Rani DS, Nand K (2004) Ensilage of pineapple processing waste for methane generation. Waste Manage 24:523–528
Banerjee S, Ranganathan V, Patti A, Arora A (2018) Valorisation of pineapple wastes for food and therapeutic applications. Trends Food Sci Technol 82(September):60–70. https://doi.org/10.1016/J.TIFS.2018.09.024
Sepúlveda L, Romaní A, Noé C, Teixeira J (2018) Valorization of pineapple waste for the extraction of bioactive compounds and glycosides using autohydrolysis. Innov Food Sci Emerg Technol 47(September 2017):38–45. https://doi.org/10.1016/j.ifset.2018.01.012
Tauseef S, Premalatha M, Abbasi T, Abbasi S (2013) Methane capture from livestock manure. J Environ Manage 117:187–207
Morais DR, Rotta EM, Sargi SC, Schmidt EM, Bonafe EG, Eberlin MN, Visentainer JV (2015) Antioxidant activity, phenolics and UPLC-ESI(-)-MS of extracts from different tropical fruits parts and processed peels. Food Res Int 77:392–399. https://doi.org/10.1016/j.foodres.2015.08.036
Selani MM, Bianchini A, Ratnayake WS, Flores RA, Massarioli AP, Alencar SM De (2016) Physicochemical , Functional and Antioxidant Properties of Tropical Fruits Co-products. Plant Foods Hum Nutr 137–144. https://doi.org/10.1007/s11130-016-0531-z
Larrauri JA, Rupérez P, Saura Calixto F (1997) Pineapple Shell as a Source of Dietary Fiber with Associated Polyphenols. J Agric Food Chem 45(10):4028–4031. https://doi.org/10.1021/jf970450j
Tochi B, Wang Z, Xu S, Zhang W (2008) Therapeutic application of pineapple protease(bromelain): A review. Pakistan JJournal of Nutrition 7(4):513–520
Setiasih S, Putri M, Handayani S, Hudiyono S (2020) The effects of PMSF and cysteine addition into partially purified bromelain from pineapple ( Ananas comosus [ L ] Merr ) cores to its kinetics behaviour The effects of PMSF and cysteine addition into partially purified bromelain from pineapple ( Ananas co. 3rd International Symposium on Current Progress in Functional Materials 76:31–5. https://doi.org/10.1088/1757-899X/763/1/012026
Roha S, Zainal S, Noriham A, Nadzirah K (2013) Determination of sugar content in pineapple waste variety N36. Int Food Res J 20(4):1941–1943
Zaki NAM, Rahman NA, Zamanhur NA, Hashib SA (2017) Ascorbic Acid Content and Proteolytic Enzyme Activity of Microwave-Dried Pineapple Stem and Core. Chem Eng Trans 56:1369–1374
Herrero M, Castro-Puyana M, Ibáñez E, Cifuentes A (2013) Compositional Analysis of Foods. Liq Chromatogr (pp. 295–317). Elsevier. https://doi.org/10.1016/B978-0-12-415806-1.00011-5
Santos DI, Martins CF, Amaral RA, Brito L, Saraiva JA, Vicente AA, Moldão-Martins M (2021) Pineapple (Ananas comosus L) By-Products Valorization: Novel Bio Ingredients for Functional Foods. Molecules 26(11):3216. https://doi.org/10.3390/molecules26113216
Alegria C, Pinheiro J, Duthoit M, Gonçalves EM, Moldão-Martins M, Abreu M (2012) Fresh-cut carrot (cv Nantes) quality as affected by abiotic stress (heat shock and UV-C irradiation) pre-treatments. LWT - Food Science and Technology 48(2):197–203. https://doi.org/10.1016/j.lwt.2012.03.013
Yazid NA, Roslan AR (2019) Production of enzymes from pineapple crown and coffee husk by solid state fermentation Production of enzymes from pineapple crown and coffee husk by solid state fermentation. 26th Regional Symposium on Chemical Engineering (RSCE 2019), 778(IOP Conf. Series: Materials Science and Engineering), 1–8. https://doi.org/10.1088/1757-899X/778/1/012035
Tran AV (2006) Chemical analysis and pulping study of pineapple crown leaves. Ind Crops Prod 24:66–74. https://doi.org/10.1016/j.indcrop.2006.03.003
Prado KS, Spinacé MAS (2019) Isolation and characterization of cellulose nanocrystals from pineapple crown waste and their potential uses. Int J Biol Macromol 122:410–416. https://doi.org/10.1016/j.ijbiomac.2018.10.187
Barbosa AS, Siqueira LAM, Medeiros RLBA, Melo DMA, Melo MAF, Freitas JCO, Braga RM (2019) Renewable aromatics through catalytic flash pyrolysis of pineapple crown leaves using HZSM-5 synthesized with RHA and diatomite. Waste Manage 88:347–355. https://doi.org/10.1016/j.wasman.2019.03.052
Martins S, Mussatto SI, Martínez-Avila G, Montañez-Saenz J, Aguilar CN, Teixeira JA (2011) Bioactive phenolic compounds: Production and extraction by solid-state fermentation. Biotechnol Adv 29:365–373
Ferrentino G, Scampicchio MM, Ferrentino G, Scampicchio MM, Ferrentino G, Scampicchio MM (2018) Current technologies and new insights for the recovery of high valuable compounds from fruits from fruits by-products, 8398. https://doi.org/10.1080/10408398.2016.1180589
Dai J, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15(10):7313–7352
Ignat I, Volf I, Popa VI (2011) A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables. Food Chem 126:1821–1835
Karakaya S (2004) Bioavailability of phenolic compounds. Crit Rev Food Sci Nutr 44(6):453–464
Lapornik B, Prošek M, Golc Wondra A (2005) Comparison of extracts prepared from plant by-products using different solvents and extraction time. J Food Eng 71:214–222
Boudet AM (2007) Evolution and current status of research in phenolic compounds. Phytochemestry 68:2722–2735
Hossain MA, Rahman SMM (2011) Total phenolics, fl avonoids and antioxidant activity of tropical fruit pineapple. FRIN 44(3):672–676. https://doi.org/10.1016/j.foodres.2010.11.036
Sopie E, Tanoh H, Kouakou L, Yatty J, Kouamé P, Mérillon J (2011) Phenolic profiles of pineapple fruits (Ananas comosus L. Merrill) Influence of the origin of suckers. Australian J Basic App Sci 5(6):1372–1378
Campos DA, Ribeiro TB, Teixeira JA, Pastrana L (2020) Integral Valorization of Pineapple ( Ananas comosus L ) By-Products through a Green Chemistry Approach towards Added Value Ingredients. Foods 9(1):1–22. https://doi.org/10.3390/foods9010060
Arora S, Itankar P (2018) Extraction, isolation and identification of flavonoid from Chenopodium album aerial parts. J Tradit Complement Med 8:476–482
Bazinet L, Labbe DP, Tremblay A (2007) Production of green teaEGC and EGCG enriched fractions by a two-step extractionprocedure. Sep Purif Technol 56:53–56
Vijaykumar L, Murchana C, Mihir Kumar P (2019) Purification of catechins from Camellia sinensis using membrane cell. Food Bioprod Process 117:203–212
Sengar AS, Sunil CK, Rawson A, Venkatachalapathy N (2022) Identification of volatile compounds, physicochemical and techno-functional properties of pineapple processing waste (PPW). J Food Measure Character 16(2):1146–1158. https://doi.org/10.1007/s11694-021-01243-8
Auras R (2012) Antioxidant Activity and Di ff usion of Catechin and Epicatechin from Antioxidant Active Films Made of Poly(. https://doi.org/10.1021/jf300668u
Bae K, Tan S, Yamashita A, Ang W, Gao S, Wang S, Kurisawa M (2017) Hyaluronic acid-green tea catechin micellar nanocomplexes: fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity. Biomaterials 148:41–53
Yilmaz Y (2006) Novel uses of catechins in foods. Trends Food Sci Technol 17(2):64–71
Dopico-García MS, Castro-López MM, López-Vilariño JM, González-Rodríguez MV, Valentao P, Andrade PB, García-Garabal S, Abad MJ (2011) Natural extracts as potential source of antioxidants to stabilize polyolefins. J Appl Polym Sci 119:3553–3559
Goleniowski M, Bonfill M, Cusido R, & Palazón J (2013) Phenolic acids. Nat Prod (pp. 1951–1973). Berlin, Heidelberg: Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_64
Sadh PK, Kumar S, Chawla P, Duhan J (2018) Fermentation: a boon for production of bioactive compounds by processing of food industries wastes (by-products). Molecules 23(10):2560. https://doi.org/10.3390/molecules23102560
Erukainure O, Sanni O, Islam M (2018) Chapter 6 - Clerodendrum volubile: phenolics and applications to health. In: Polyphenols: mechanisms of action in human health and disease (Second). Academic Press, pp 53–68
Embuscado ME (2015) Spices and herbs: natural sources of antioxidants-a mini review. J Functional Foods 18:811–819
Cruz Rosas E, Barbosa Correa L, & Henriques-Graças M (2019) Chapter 28 - Antiinflammatory Properties of Schinus terebinthifolius and Its Use in Arthritic Conditions. In Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second, pp. 489–505). Academic Press
Ou S, Kwork K (2004) Review ferulic acid: Pharmaceutical functions, preparation and applications in foods. J Sci Food Agric 3(2B):53–56
Ong K, Wai T, Ling L (2014) Pineapple cannery waste as a potential substrate for microbial biotransformation to produce vanillic acid and vanillin. Int Food Res J 21(3):953–958
Grand View Research (2017) Vanillin market analysis, by end-use (food & beverage, fragrance, pharmaceutical), by region (North America, Europe, Asia Pacific, central & South America, MEA), and segment forecasts, 2018 - 2025. Retrieved from https://www.grandviewresearch.com/industry-analysis/vanillin-market.
Saraswaty V, Risdian C, Primadona I, Andriyani R, Andayani DGS, Mozef T (2017) Pineapple peel wastes as a potential source of antioxidant compounds. IOP Conference Series: Earth and Environmental Science 60:012013. https://doi.org/10.1088/1755-1315/60/1/012013
Sah BNP, Vasiljevic T, McKechnie S, Donkor ON (2016) Physicochemical, textural and rheological properties of probiotic yogurt fortified with fibre-rich pineapple peel powder during refrigerated storage. LWT - Food Science and Technology 65:978–986. https://doi.org/10.1016/j.lwt.2015.09.027
Selani M, Guidolin S, Tadeu C, Ratnayake WS, Flores RA, Bianchini A (2014) Characterisation and potential application of pineapple pomace in an extruded product for fibre enhancement. Food Chemistry 163:23–30. https://doi.org/10.1016/j.foodchem.2014.04.076
Chaurasiya RS, Umesh Hebbar H (2013) Extraction of bromelain from pineapple core and purification by RME and precipitation methods. Sep Purif Technol 111:90–97. https://doi.org/10.1016/j.seppur.2013.03.029
Leão DP, Franca AS, Oliveira LS, Bastos R, Coimbra MA (2017) Physicochemical characterization, antioxidant capacity, total phenolic and proanthocyanidin content of flours prepared from pequi (Caryocar brasilense Camb.) fruit by-products. Food Chem 225:146–153. https://doi.org/10.1016/j.foodchem.2017.01.027
Gomez S, Kuruvila B, Maneesha PK, Joseph M (2022) Variation in physico-chemical, organoleptic and microbial qualities of intermediate moisture pineapple (Ananas comosus (L) Merr) slices during storage. Food Prod, Process Nutri 4(1):5. https://doi.org/10.1186/s43014-022-00084-2
Martins N, Ferreira ICFR (2017) Wastes and by-products: Upcoming sources of carotenoids for biotechnological purposes and health-related applications. Trends Food Sci Technol 62:33–48. https://doi.org/10.1016/j.tifs.2017.01.014
Wen P, Hu T, Linhardt RJ, Liao S, Wu H, Zou Y (2019) Trends in Food Science & Technology Mulberry : A review of bioactive compounds and advanced processing technology. Trends in Food Sci Technol 83(November 2018):138–158. https://doi.org/10.1016/j.tifs.2018.11.017
Giacometti JD, BursaćKovačević P, Putnik D, Gabrić T, Bilušić G, Krešić V, Stulić FJ, RežekJambrak A (2018) Extraction of bioactive compounds and essential oils from mediterranean herbs by conventional and green innovative techniques: A review. Food Res Int 113:245–262. https://doi.org/10.1016/j.foodres.2018.06.036
Wang L, Weller CL (2006) Recent advances in extraction of nutraceuticals from plants. Trends Food Sci Technol 17:300–312
Aires A (2017) Phenolics in foods: Extraction, analysis and measurements. In M. Soto-Hernandez, M. Palma-Tenango, & M. del R. Garcia-Mateos (Eds.), Phenolic compounds: Natural sources, importance and applications. (2833). https://doi.org/10.5772/66889
Rombaut NA, Tixier A-S, Bily A, Chemat F (2014) Green extraction processes of natural products as tools for biorefinery. Biofuels, Bioprod Biorefin 8(4):530–544
Roselló-Soto E, Koubaa M, Moubarik A, Lopes RP, Saraiva JA, Boussetta N (2015) Emerging opportunities for the effective valorization of wastes and by-products generated during olive oil production process: non-conventional methods for the recovery of high-added value compounds. Trends Food Sci Technol 45(2):296–310
Barba FJ, Grimi N, Vorobiev E (2015) Evaluating the potential of cell disruption technologies for green selective extraction of antioxidant compounds from Stevia rebaudiana Bertoni leaves. J Food Eng 149:222–228
Galanakis CM, Barba FJ, Prasad KN (2015) Cost and safety issues of emerging technologies against conventional techniques. Food Waste Recover Process Technol Ind Technol (pp. 323–338)
Galanakis CM, Rizou M, Aldawoud TMS, Ucak I, Rowan NJ (2021) Innovations and technology disruptions in the food sector within the COVID-19 pandemic and post-lockdown era. Trends Food Sci Technol 110:193–200. https://doi.org/10.1016/j.tifs.2021.02.002
Koirala S, Prathumpai W, Anal AK (2021) Effect of ultrasonication pretreatment followed by enzymatic hydrolysis of caprine milk proteins and on antioxidant and angiotensin converting enzyme (ACE) inhibitory activity of peptides thus produced. Int Dairy J 118:105026. https://doi.org/10.1016/j.idairyj.2021.105026
Silveira da Rosa G, Vanga SK, Gariepy Y, Raghavan V (2019) Comparison of microwave, ultrasonic and conventional techniques for extraction of bioactive compounds from olive leaves (Olea europaea L). Innovative Food Science & Emerging Technologies 58:102234. https://doi.org/10.1016/j.ifset.2019.102234
Wen C, Zhang J, Zhang H, Dzah CS, Zandile M (2018) Advances in ultrasound assisted extraction of bioactive compounds from cash crops – A review. Ultrasonics - Sonochem 48(June):538–549. https://doi.org/10.1016/j.ultsonch.2018.07.018
Panzella L, Moccia F, Nasti R, Marzorati S, Verotta L, Napolitano A (2020) Bioactive Phenolic Compounds From Agri-Food Wastes : An Update on Green and Sustainable Extraction Methodologies 7(May):1–27. https://doi.org/10.3389/fnut.2020.00060
Talmaciu A, Volf I, Popa VI (2015) A comparative analysis of the “green” techniques applied for polyphenols extraction from bioresources. Chem Biodiversity 12:1635–1651. https://doi.org/10.1002/cbdv.201400415
Tiwari BK (2015) Ultrasound: A clean, green extraction technology. TrAC, Trends Anal Chem 71:100–109. https://doi.org/10.1016/j.trac.2015.04.013
Chemat FN, Rombaut AG, Sicaire A, Meullemiestre A, FabianoTixier S, Abert-Vian M (2017) Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A Rev Ultrasonics Sonochem 34:540–560. https://doi.org/10.1016/j.ultsonch.2016.06.035
Setyaningsih W, Saputro IE, Carrera CA, Palma M (2019) Optimisation of an ultrasound-assisted extraction method for the simultaneous determination of phenolics in rice grains. Food Chem 288:221–227. https://doi.org/10.1016/j.foodchem.2019.02.107
Martínez R, Torres P, Meneses MA, Figueroa JG, Pérez-álvarez JA, Viuda-martos M (2012) Chemical, technological and in vitro antioxidant properties of mango, guava, pineapple and passion fruit dietary fibre concentrate. Food Chem 135(3):1520–1526. https://doi.org/10.1016/j.foodchem.2012.05.057
Hernández-Santos B, Rodríguez-Miranda J, Herman-Lara E, Torruco-Uco JG, Carmona-García R, Juárez-Barrientos JM, Martínez-Sánchez CE (2016) Effect of oil extraction assisted by ultrasound on the physicochemical properties and fatty acid profile of pumpkin seed oil (Cucurbita pepo). Ultrason Sonochem 31:429–436. https://doi.org/10.1016/j.ultsonch.2016.01.029
Rathnakumar K, Anal AK, Lakshmi K (2017) Optimization of Ultrasonic Assisted Extraction of Bioactive components from different Parts of Pineapple Waste. Int J Agri, Environ Biotechnol 10(5):553. https://doi.org/10.5958/2230-732X.2017.00068.7
Liu SH, Liu YG, Zhang XM (2018) Extraction conditions and antioxidant activities of the extract of pineapple peel by ultrasonic. IOP Conference Series: Earth and Environmental Science 186:012038
Yahya NA, Wahab RA, Shuh TL, & Hamid MA (2019) Ultrasound-assisted extraction of polyphenols from pineapple skin Ultrasound-Assisted Extraction of Polyphenols from Pineapple Skin, 020002(September)
Carlqvist K, Wallberg O, Lidén G, Börjesson P (2022) Life cycle assessment for identification of critical aspects in emerging technologies for the extraction of phenolic compounds from spruce bark. J Clean Prod 333:130093. https://doi.org/10.1016/j.jclepro.2021.130093
Kataoka H (2018) Pharmaceutical analysis | sample preparation. In: Reference module in chemistry, molecular sciences and chemical engineering. Elsevier. https://doi.org/10.1016/B978-0-12-409547-2.14358-6
Leadbeater NE (2014) Organic synthesis using microwave heating. reference module in chemistry, molecular sciences and chemical engineering. In P. Knochel & G. A. Molander (Eds.), Comprehensive organic synthesis (2nd., pp. 234–286). Elsevier. https://doi.org/10.1016/B978-0-08-097742-3.00920-4
Oroian M, Escriche I (2015) Antioxidants: Characterization, natural sources, extraction and analysis. Food Res Int 74:10–36
Alias NH, Abbas Z (2017) Preliminary Investigation on the Total Phenolic Content and Antioxidant Activity of Pineapple Wastes via Microwave- Assisted Extraction at Fixed Microwave Power. Chem Eng Trans 56(2009):1675–1680. https://doi.org/10.3303/CET1756280
Alias Halaliza N, Abbas Z (2017) Microwave-assisted extraction of phenolic compound from pineapple skins: the optimum operating condition and comparison with soxhlet extraction. Malaysian J Anal Sci 21(3):690–699. https://doi.org/10.17576/mjas-2017-2103-18
Hatam SF, Suryanto E, Abidjulu J (2013) Aktivitas antioksidan dari ekstrak kulit nenas (Ananas comosus (L) Merr). Pharma, J Ilmiah Farmasi 2(1):2310–2315
Akhtar Zakaria N, Rahman RA, Norulfairuz D, Zaidel A, Dailin DJ, Jusoh M (2021) Microwave-assisted extraction of pectin from pineapple peel Article history. In / Malaysian Journal of Fundamental and Applied Sciences (Vol. 17, Issue 1).
Subramaniyam R, Vimala R (2012) Solid state and submerged fermentation for the production of bioactive substances: a comparative study. Int J Sci Nat 3(3):480–486
Prado Barragán LA, Figueroa JJB, Rodríguez Durán LV, Aguilar González CN, Hennigs C (2016) Fermentative Production Methods. In Biotransformation of Agricultural Waste and By-Products (pp. 189–217). https://doi.org/10.1016/B978-0-12-803622-8.00007-0
Suriya J, Bharathiraja S, Krishnan M, Manivasagan P, & Kim SK (2016) Marine Microbial Amylases: Properties and Applications. In S.-K. Kim & F. Toldrá (Eds.), Adv Food Nutr Res (pp. 161–177). https://doi.org/10.1016/bs.afnr.2016.07.001
Beitel SM, Knob A (2013) Penicillium miczynskii b-glucosidase: A Glucose-Tolerant Enzyme Produced Using Pineapple Peel as Substrate. Ind Biotechnol 9(5):293–301. https://doi.org/10.1089/ind.2013.0016
Rashad MM, Mahmoud AE, Ali MM, Nooman MU, Amr S (2016) Antioxidant and Anticancer Agents Produced from Pineapple Waste by Solid State Fermentation 7(6):287–296
Mensah JKM, Twumasi P (2017) Use of pineapple waste for single cell protein ( SCP ) production and the e ff ect of substrate concentration on the yield, (July 2016), 1–9. https://doi.org/10.1111/jfpe.12478
Abdullah A, Winaningsih I (2020) Effect of some parameter on lactic acid fermentation from pineapple waste by Lactobacillus delbrueckii. AIP Conferences Proceedings 060002(January):1–8. https://doi.org/10.1063/1.5140929
Abdel-Rahman MA, Tashiro Y, Sonomoto K (2013) Recent advances in lactic acid production by microbial fermentation processes. Biotechnol Adv 31(6):877–902. https://doi.org/10.1016/j.biotechadv.2013.04.002
Kumar PGV, Paul SK, Khobragade CB, Bania BK, Sengupta DK (2020) Requirements of mixed tangerine (Citrus tangerine) and pineapple (Ananas comosus) powdered peel wastes fermentation for citric acid production. Agric Eng Int CIGR J 22(2):194–207
Sharma R, Oberoi HS, Dhillon GS (2016) Fruit and Vegetable Processing Waste. In Agro-Industrial Wastes as Feedstock for Enzyme Production (pp. 23–59). Elsevier. https://doi.org/10.1016/B978-0-12-802392-1.00002-2
Doriya K, Jose N, Gowda M, Kumar DS (2016) Solid-State Fermentation vs Submerged Fermentation for the Production of l-Asparaginase (pp. 115–135). https://doi.org/10.1016/bs.afnr.2016.05.003
Thomas L, Larroche C, Pandey A (2013) Current developments in solid-state fermentation. Biochem Eng J 81:146–161. https://doi.org/10.1016/j.bej.2013.10.013
Webb C, Manan MA (2017) Design aspects of solid state fermentation as applied to microbial bioprocessing. J App Biotechnol Bioeng 4(1):511–532
Cho KM, Hong SY, Math RK, Lee JH, Kambiranda DM, Kim JM, … Yun HD (2008) Biotransformation of phenolics (isoflavones, flavanols and phenolic acids) during the fermentation of cheonggukjang by Bacillus pumilus HY1. Food Chem 114:413–419
Imandi S, Bandaru V, Somalanka S, Bandaru S, Garapati H (2008) Application of statistical experimental designs of medium constituents for the production of citric acid from pineapple waste. Biores Technol 99(10):4445–4450
Ciriminna R, Meneguzzo F, Delisi R, Pagliaro M (2017) Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J 11(1):22. https://doi.org/10.1186/s13065-017-0251-y
Sousa BA, Correia RTP (2012) Phenolic content, antioxidant activity and antiamylolytic activity of extracts obtained from bioprocessed pineapple and guava wastes. Braz J Chem Eng 29:25–30
Aziman SN, Tumari HH, Zain NAM (2015) Determination of lactic acid production by Rhizopus Oryzae in solid state fermentation of pineapple waste. Jurnal Teknologi 77(31):95–102
Zain NAM, Aziman SN, Suhaimi MS, Idris A (2021) Optimization of L(+) lactic acid production from solid pineapple waste (SPW) by Rhizopus oryzae NRRL 395. J Polym Environ 29(1):230–249. https://doi.org/10.1007/s10924-020-01862-0
Aruna TE (2019) Production of value-added products from pineapple peels using solid state fermentation. Innov Food Sci Emerg Technol 57:102193. https://doi.org/10.1016/j.ifset.2019.102193
Yazid NA, Roslan AR (2020). Production of enzymes from pineapple crown and coffee husk by solid state fermentation Production of enzymes from pineapple crown and coffee husk by solid state fermentation. https://doi.org/10.1088/1757-899X/778/1/012035
Badhani B, Sharma N, Kakkar R (2015) Gallic Acid: A Versatile Antioxidant with Promising Therapeutic and Industrial Applications. RSC Adv 5(35):27540–27557. https://doi.org/10.1039/C5RA01911G
Chia YC, Rajbanshi R, Calhoun C, Chiu RH (2010) Anti-neoplastic Effects of Gallic Acid, a Major Component of Toona Sinensis Leaf Extract, on Oral Squamous Carcinoma Cells. Molecules 15(11):8377–8389. https://doi.org/10.3390/molecules15118377
Inoue M, Suzuki R, Sakaguchi T, Lee M, Takeda T, Ogiwara Y, … Chen H (1995) Selective Induction of Cell Death in Cancer Cells by Gallic Acid. Biol Pharm Bull 18(11):1526–1530
Kim M, Seong A, Yoo J, Jin C, Lee Y, Kim YJ, … Yoon H (2011) Gallic acid, a histone acetyltransferase inhibitor, suppresses β‐amyloid neurotoxicity by inhibiting microglial‐mediated neuroinflammation.Mol Nutr Food Res 55(12):1798–1808https://doi.org/10.1002/mnfr.201100262
Ohno T, Inoue M, Ogihara Y (2001) Cytotoxic Activity of Gallic Acid against Liver Metastasis of Mastocytoma Cells P-815. Anticancer Res 21(6A):3875–3880
Ohno Y, Fukuda K, Takemura G, Toyota M, Watanabe M, Yasuda N, … Fujiwara H (1999) Induction of Apoptosis by Gallic Acid in Lung Cancer Cells. Anti Cancer Drugs 10(9):845–851https://doi.org/10.1097/00001813-199910000-00008
Patel SS, Goyal RK (2011) Cardioprotective Effects of Gallic Acid in Diabetes-induced Myocardial Dysfunction in Rats. Pharma Res 3(4):239–245. https://doi.org/10.4103/0974-8490.89743
Priscilla DH, Prince PSM (2009) Cardioprotective Effect of Gallic Acid on Cardiac troponin-T, Cardiac Marker Enzymes, Lipid Peroxidation Products and Antioxidants in Experimentally Induced Myocardial Infarction in Wistar Rats. Chem Biol Interact 179(2–3):118–124. https://doi.org/10.1016/j.cbi.2008.12.012
Rasool MK, Sabina EP, Ramya SR, Preety P, Patel S, Mandal N, … Samuel J (2010) Hepatoprotective and antioxidant effects of gallic acid in paracetamol‐induced liver damage in mice. J Pharm Pharmacol 62(5):638–643. https://doi.org/10.1211/jpp.62.05.0012
Veluri R, Singh RP, Liu Z, Thompson JA, Agarwal R, Agarwal C (2006) Fractionation of Grape Seed Extract and Identification of Gallic Acid as One of the Major Active Constituents Causing Growth Inhibition and Apoptotic Death of DU145 Human Prostate Carcinoma Cells. Carcinogenesis 27(7):1445–1453. https://doi.org/10.1093/carcin/bgi347
Yu M, Chen X, Liu J, Ma Q, Zhuo Z, Chen H, … Hou ST (2019) Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse. Neurobiol Dis 124:67–80. https://doi.org/10.1016/j.nbd.2018.11.009
Zhou Y, Jin G, Mi R, Dong C, Zhang J, Liu F (2014) Neuroprotective Effects of Gallic Acid against Hypoxia/reoxygenation-induced Mitochondrial Dysfunctions in Vitro and Cerebral Ischemia/reperfusion Injury in Vivo. Brain Res 1556:57–66. https://doi.org/10.1016/j.brainres.2014.09.039
Steingass CB, Glock MP, Schweiggert RM, Carle R (2015) Studies into the phenolic patterns of different tissues of pineapple (Ananas comosus [L] Merr) infructescence by HPLC-DAD-ESI-MS n and GC-MS analysis. Anal Bioanal Chem 407(21):6463–6479. https://doi.org/10.1007/s00216-015-8811-2
Lourenço SC, Campos DA, Gómez-García R, Pintado M, Oliveira MC, Santos DI, Corrêa-Filho LC, Moldão-Martins M, Alves VD (2021) Optimization of Natural Antioxidants Extraction from Pineapple Peel and Their Stabilization by Spray Drying. Foods 10(6):1255. https://doi.org/10.3390/foods10061255
Du L, Sun G, Zhang X, Liu Y, Prinyawiwatkul W, Xu Z, Shen Y (2016) Comparisons and correlations of phenolic profiles and anti-oxidant activities of seventeen varieties of pineapple. Food Sci Biotechnol 25(2):445–451. https://doi.org/10.1007/s10068-016-0061-3
Rasheed AA, Cobham EI, Zeighami M, & Ong SP (2012) Extraction of phenolic compounds from pineapple fruit. Proceedings of the 2nd International Symposium on Processing & Drying of Foods, Fruits & Vegetables 1–8
Gu R, Zhang M, Hu M, Xu D, Xie Y (2018) Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition. Biomed Pharmacother 105:491–497. https://doi.org/10.1016/j.biopha.2018.05.158
Zhu L, Gu P, Shen H (2019) Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis. Int Immunopharmacol 67:129–137. https://doi.org/10.1016/j.intimp.2018.11.049
Fang Lz, Lin D, Warner RD, Ha M (2018) Effect of gallic acid/chitosan coating on fresh pork quality in modified atmosphere packaging. Food Chem 260:90–96. https://doi.org/10.1016/j.foodchem.2018.04.005
Zhao Y, Saldaña MDA (2019) Use of potato by-products and gallic acid for development of bioactive film packaging by subcritical water technology. J Supercritical Fluids 143:97–106. https://doi.org/10.1016/j.supflu.2018.07.025
Zhang X-K, He F, Zhang B, Reeves MJ, Liu Y, Zhao X, Duan C-Q (2018) The effect of prefermentative addition of gallic acid and ellagic acid on the red wine color, copigmentation and phenolic profiles during wine aging. Food Res Int 106:568–579. https://doi.org/10.1016/j.foodres.2017.12.054
Yadav S, Mehrotra GK, Dutta PK (2021) Chitosan based ZnO nanoparticles loaded gallic-acid films for active food packaging. Food Chem 334:127605. https://doi.org/10.1016/j.foodchem.2020.127605
Atoui AK, Mansouri A, Boskou G, Kefalas P (2005) Tea and herbal infusions: Their antioxidant activity and phenolic profile. Food Chem 89:27–36
Bae J, Kim N, Shin Y, Kim S-Y, Kim Y-J (2020) Activity of catechins and their applications. Biomed Dermatol 4(20):1–10. https://doi.org/10.1186/s41702-020-0057-8
Xu Zhimin, Howard LR (2012) Analysis of Antioxidant-Rich Phytochemicals. Wiley-Blackwell. Inc., Hoboken, NJ, USA. pp. 1-16. https://doi.org/10.1002/9781118229378
Ruengdech A, Siripatrawan U (2021) Application of catechin nanoencapsulation with enhanced antioxidant activity in high pressure processed catechin-fortified coconut milk. LWT - Food Science and Technology 140(April 2021):110594. https://doi.org/10.1016/j.lwt.2020.110594
Kaewprachu P, Amara CB, Oulahal N, Gharsallaoui A, Joly C, Tongdeesoontorn W, Degraeve P (2018) Gelatin films with nisin and catechin for minced pork preservation. Food Packaging and Shelf Life 18(December 2018):173–183. https://doi.org/10.1016/j.fpsl.2018.10.011
Rawdkuen S, Suthiluk P, Kamhangwong D, Benjakul S (2012) Mechanical, physico-chemical, and antimicrobial properties of gelatin-based film incorporated with catechin-lysozyme. Chem Cent J 6(1):131. https://doi.org/10.1186/1752-153X-6-131
Gallego MG, Skowyra M, Gordon MH, Azman NAM, Almajano MP (2017) Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions. Antioxidants 6(1):1–17. https://doi.org/10.3390/antiox6010019
Spizzirri UG, Iemma F, Puoci F, Cirillo G, Curcio M, Parisi OI, Picci N (2009) Synthesis of antioxidant polymers by grafting of gallic acid and catechin on gelatin. Biomacromol 10(7):1923–1930. https://doi.org/10.1021/bm900325t
Gopal J, Muthu M, Paul D, Kim D-H, Chun S (2016) Bactericidal activity of green tea extracts: the importance of catechin containing nano particles. Sci Rep 6:1–14. https://doi.org/10.1038/srep19710
Goyal AK, Bhat M, Sharma M, Garg M, Khairwa A, Garg R (2017) Effect of green tea mouth rinse on Streptococcus mutans in plaque and saliva in children: An in vivo study. J Indian Soc Pedodoncitics Preventive Dentistry 35(1):41–46. https://doi.org/10.4103/0970-4388.199227
Ganeshpurkar A, Saluja AK (2018) Protective effect of catechin on humoral and cell mediated immunity in rat model. Int Immunopharmacol 54(January 2018):261–266. https://doi.org/10.1016/j.intimp.2017.11.022
Logsdon AL, Herring BJ, Lockard JE, Miller BM, Kim H, Hood RD, Bailey MM (2012) Exposure to green tea extract alters the incidence of specific cyclophosphamide-induced malformations. Develop Reprod Toxicol 95(3):231–237. https://doi.org/10.1002/bdrb.21011
Sun H, Yin M, Hao D, Shen Y (2020) Anti-Cancer Activity of Catechin against A549 Lung Carcinoma Cells by Induction of Cyclin Kinase Inhibitor p21 and Suppression of Cyclin E1 and P-AKT. Appl Sci 10(6):1–8. https://doi.org/10.3390/app10062065
Kumar M, Chandel M, Kaur P, Pandit K, Kaur V, Kaur S, Kaur S (2016) Chemical composition and inhibitory effects of water extract of Henna leaves on reactive oxygen species, DNA scission and proliferation of cancer cells. EXCLI Journal 15:842–857. https://doi.org/10.17179/excli2016-429
Manikandan R, Beulaja M, Arulvasu C, Sellamuthu S, Dinesh D, Prabhu D, … Prabhu N (2012) Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines. Microsc Res Tech 75(2):112–116. https://doi.org/10.1002/jemt.21032
Zheng JS, Yang J, Fu YQ, Huang T, Huang YJ, Li D (2013) Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer: A systematic review and meta-analysis of observational studies. Nutr Cancer 65(1):1–16
Addepalli V, Suryavanshi SV (2018) Catechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats. Biomed Pharmacother 108:1517–1523. https://doi.org/10.1016/j.biopha.2018.09.179
Abdulkhaleq LA, Assi MA, Noor MHM, Abdullah R, Saad MZ, Taufiq-Yap YH (2017) Therapeutic uses of epicatechin in diabetes and cancer. Veterinary World 10(8):869–872. https://doi.org/10.14202/vetworld.2017.869-872
Azizan A, Lee AX, Abdul Hamid NA, Maulidiani M, Mediani A, Abdul Ghafar SZ, Zolkeflee NKZ, Abas F (2020) Potentially Bioactive Metabolites from Pineapple Waste Extracts and Their Antioxidant and α-Glucosidase Inhibitory Activities by 1H NMR. Foods 9(2):173. https://doi.org/10.3390/foods9020173
Lawal U, Maulidiani M, Shaari K, Ismail IS, Khatib A, Abas F (2017) Discrimination of Ipomoea aquatica cultivars and bioactivity correlations using NMR-based metabolomics approach. Plant Biosys - An Int J Deal All Aspects of Plant Biol 151(5):833–843. https://doi.org/10.1080/11263504.2016.1211198
Tadera K, Minami Y, Takamatsu K, Matsuoka T (2006) Inhibition of ALPHA-Glucosidase and ALPHA-Amylase by Flavonoids. J Nutrition Sci Vitaminol 52(2):149–153. https://doi.org/10.3177/jnsv.52.149
Morrison M, Van der Heijden R, Heeringa P, Kaijzel E, Verschuren L, Blomhoff R, Kleemann R (2014) Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB in vivo. Atherosclerosis 233(1):149–156. https://doi.org/10.1016/j.atherosclerosis.2013.12.027
Zhang H, Deng A, Zhang H, Yu Z, Liu Y, Peng S, … Wang W (2016) The protective effect of epicatechin on experimental ulcerative colitis in mice is mediated by increasing antioxidation and by the inhibition of NF-κB pathway. Pharmacol Rep 68(3):514–520. https://doi.org/10.1016/j.pharep.2015.12.011
Zhang X, Lin D, Jiang R, Li H, Wan J, Li H (2016) Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition. Oncol Rep 36(1):271–278. https://doi.org/10.3892/or.2016.4804
Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza PI (2016) Anti-inflammatory actions of (−)-epicatechin in the adipose tissue of obese mice. The Int J Biochem Cell Biol 81(Part B):383–392. https://doi.org/10.1016/j.biocel.2016.08.044
Xu M, Sun M, Lu C, Han Y, Yao X, Niu X, Zhu Q (2020) Influence of epicatechin on oxidation-induced physicochemical and digestibility changes in porcine myofibrillar proteins during refrigerated storage. J Sci Food Agric 101(2):746–753. https://doi.org/10.1002/jsfa.10687
Iñiguez-Franco F, Soto-Valdez H, Peralta E, Ayala-Zavala JF, Auras R, Gamez-Meza N (2012) Antioxidant Activity and Diffusion of Catechin and Epicatechin from Antioxidant Active Films Made of Poly(l-lactic acid). J Agric Food Chem 60(26):6515–6523. https://doi.org/10.1021/jf300668u
Shariati S, Kalantar H, Pashmforoosh M, Mansouri E, Khodayar MJ (2019) Epicatechin protective effects on bleomycin-induced pulmonary oxidative stress and fibrosis in mice. Biomed Pharma 114(June 2019):108776. https://doi.org/10.1016/j.biopha.2019.108776
Rein D, Lotito S, Holt RR, Keen CL, Schmitz HH, Fraga CG (2000) Epicatechin in human plasma In vivo determination and effect of chocolate consumption on plasma oxidation status. J Nutr 130(8):2109S-2114S. https://doi.org/10.1093/jn/130.8.2109S
Josic J, Olsson AT, Wickeberg J, Lindstedt S, Hlebowicz J (2010) Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: A randomized controlled trial. Nutr J 9(63):1–8
Cremonini E, Bettaieb A, Haj FG, Fraga CG, Oteiza PI (2016) (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys 599:13–21. https://doi.org/10.1016/j.abb.2016.03.006
Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A (2013) Dietary (poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18(14):1818–1892
Galleano M, Bernatova I, Puzserova A, Balis P, Sestakova N, Pechanova O, Fraga CG (2013) (–)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism. IUBMB Life 65(8):710–715
Lee Y-H, Kwak J, Choi H-K, Choi K-C, Kim S, Lee J, … Yoon H-G (2012) EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity. Int J Mol Med 30(1):69–74. https://doi.org/10.3892/ijmm.2012.966
Siddique HR, Liao DJ, Mishra SK, Schuster T, Wang L, Matter B, … Saleem M (2012) Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. Int J Cancer 131(7):1720–1731. https://doi.org/10.1002/ijc.27409
Rodriguez M, Du G-J, Wang C-Z, Yuan C-S (2010) Letter to the Editor: Panaxadiol’s Anticancer Activity is Enhanced by Epicatechin. Am J Chin Med 38(6):1233–1235. https://doi.org/10.1142/S0192415X10008597
Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M (2015) Molecular mechanisms and therapeutic effects of (–)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegeneration. Oxid Med Cell Longev 2015:181260. https://doi.org/10.1155/2015/181260
Li L, Ji H (2019) Protective effects of epicatechin on the oxidation and N-nitrosamine formation of oxidatively stressed myofibrillar protein. Int J Food Prop 22(1):186–197. https://doi.org/10.1080/10942912.2019.1578792
Kumar N, Vikas P (2014) Potential applications of ferulic acid from natural sources. Biotechnol Rep 4(December 2014):86–93. https://doi.org/10.1016/j.btre.2014.09.002
Tilay A, Bule M, Kishenkumar J, Annapure U (2008) Preparation of Ferulic Acid from Agricultural Wastes: Its Improved Extraction and Purification. J Agric Food Chem 56(17):7644–7648. https://doi.org/10.1021/jf801536t
Lesage-Meessen L, Delattre M, Haon M, Thibault J-F, Ceccaldi BC, Brunerie P, Asther M (1996) A two-step bioconversion process for vanillin production from ferulic acid combining Aspergillus niger and Pycnoporus cinnabarinus. J Biotechnol 50(2–3):107–113. https://doi.org/10.1016/0168-1656(96)01552-0
Tang PL, Hassan O (2020) Bioconversion of ferulic acid attained from pineapple peels and pineapple crown leaves into vanillic acid and vanillin by Aspergillus niger I-1472. BMC Chemistry 14(7):1–11. https://doi.org/10.1186/s13065-020-0663-y
Aragón-Gutiérrez A, Rosa E, Gallur M, López D, Hernández-Muñoz P, Gavara R (2020) Melt-Processed Bioactive EVOH Films Incorporated withFerulic Acid. Polymers 13(1):1–18. https://doi.org/10.3390/polym13010068
Yu JY, Roh SH, Park HJ (2021) Characterization of ferulic acid encapsulation complexes with maltodextrin and hydroxypropyl methylcellulose. Food Hydrocolloids 111:106390. https://doi.org/10.1016/j.foodhyd.2020.106390
Pluemsamran T, Onkoksoong T, Panich U (2012) Caffeic Acid and Ferulic Acid Inhibit UVA-Induced Matrix Metalloproteinase-1 through Regulation of Antioxidant Defense System in Keratinocyte HaCaT Cells. Photochem Photobiol 88(4):961–968. https://doi.org/10.1111/j.1751-1097.2012.01118.x
Ambothi K, Nagarajan RP (2014) Ferulic acid prevents ultraviolet-B radiation induced oxidative DNA damage in human dermal fibroblasts. Int J Nutri, Pharmacol, Neurol Dis 4(4):203–213. https://doi.org/10.4103/2231-0738.139400
Karimvand MN, Kalantar H, Khodayar MJ (2020) Cytotoxic and Apoptotic Effects of Ferulic Acid on Renal Carcinoma Cell Line (ACHN). Jundishapur J Nat Pharma Prod 15(4):e81969. https://doi.org/10.5812/jjnpp.81969
Gao J, Yu H, Guo W, Kong Y, Gu L, Li Q, … Wang Y (2018) The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells. Cancer Cell Int 18(102):1–9. https://doi.org/10.1186/s12935-018-0595-y
Szulc-Kielbik I, Kielbik M, Klink M (2017) Ferulic acid but not alpha-lipoic acid effectively protects THP-1-derived macrophages from oxidant and pro-inflammatory response to LPS. Immunopharmacol Immunotoxicol 39(6):330–337. https://doi.org/10.1080/08923973.2017.1369100
El-Ashmawy NE, Khedr NF, El-Bahrawy HA, Helal SA (2018) Upregulation of PPAR-γ mediates the renoprotective effect of omega-3 PUFA and ferulic acid in gentamicin-intoxicated rats. Biomed Pharma 99(March 2018):504–510. https://doi.org/10.1016/j.biopha.2018.01.036
Sangeeta D, Digvijay S, Pradeep TD, Rupesh S, Rahul T (2015) Healing potential of ferulic acid on dermal wound in diabetic animals. Asian J Mole Model 1:1–16
Oresajo C, Stephens T, Hino PD (2008) Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. J Cosmet Dermatol 7(4):290–297. https://doi.org/10.1111/j.1473-2165.2008.00408.x
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The authors are grateful to Alejandro Florez and Ana Lucía Rengifo for your comments and advice during the writing of this document.
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Highlights
• The use of pineapple waste is a great alternative to mitigate current environmental problems.
• Green extraction technologies (ultrasound, microwave, liquid or solid fermentation) are of great interest due to the good yields of bioactive compounds obtained.
• The bioactive compounds present high antioxidant, anti-inflammatory, antifungal and anticancer activity.
• The bioactive compounds identified in pineapple by-products can be applied in food products or used in the development of pharmacological or cosmetic products.
• One of the most studied compounds is gallic acid, which has demonstrated excellent metabolic and anti-inflammatory effects, and has been used as an additive to develop edible coatings.
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Polanía, A.M., Londoño, L., Ramírez, C. et al. Valorization of pineapple waste as novel source of nutraceuticals and biofunctional compounds. Biomass Conv. Bioref. 13, 3593–3618 (2023). https://doi.org/10.1007/s13399-022-02811-8
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DOI: https://doi.org/10.1007/s13399-022-02811-8