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Ultrasound-negative pressure cavitation extraction of paclitaxel from Taxus chinensis

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Abstract

An ultrasound-negative pressure cavitation extraction method was developed to remarkably improve the recovery efficiency of paclitaxel from Taxus chinensis. The paclitaxel yield was 94–100% through ultrasound-negative pressure cavitation extraction with an extraction time of 3 to 8 min. In particular, most paclitaxel could be recovered within 3 min of extraction at ultrasonic power of 380 W/negative pressure of −260 mmHg. Observation of the biomass surface with SEM before and after extraction showed that as the ultrasonic power and negative pressure increased, the surface was more disrupted. In addition, a pseudo-second order model was suitable for the kinetic analysis, and intraparticle diffusion played a dominant role in the overall extraction rate according to the intraparticle diffusion model. As the ultrasonic power and negative pressure increased, the extraction rate constant (6.8816–11.6105 mL/mg·min), the effective diffusion coefficient (1.550×10−12–11.528×10−12 m2/s), and the mass transfer coefficient (2.222×10−7–5.149×10−7 m/s) increased.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186).

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Authors and Affiliations

  1. Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea

    Hye-Su Min, Hak-Gyun Kim & Jin-Hyun Kim

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  1. Hye-Su Min
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  2. Hak-Gyun Kim
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  3. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Min, HS., Kim, HG. & Kim, JH. Ultrasound-negative pressure cavitation extraction of paclitaxel from Taxus chinensis. Korean J. Chem. Eng. 39, 398–407 (2022). https://doi.org/10.1007/s11814-021-1028-5

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  • DOI: https://doi.org/10.1007/s11814-021-1028-5

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