Strategies for the recovery of bioactive molecules from deep eutectic solvents extracts

https://doi.org/10.1016/j.trac.2022.116798Get rights and content

Highlights

  • •

    Deep eutectic solvents are suitable to extract food and plants bioactive molecules.

  • •

    Deep eutectic solvent low vapor tension represents a drawback in extraction process.

  • •

    Strategies to recover analytes from deep eutectic solvent extracts were developed.

Abstract

The need to reduce the ecological impact of the extraction and analysis processes waste has led to use alternative green solvents. Therefore, the use of solvents such as deep eutectic solvents (DESs), natural deep eutectic solvents (NADESs), and low transition temperature mixtures (LTTMs) has increasingly applied to extraction and recovery of bioactive molecules. DESs show superior extraction capabilities compared to common organic solvents, both in terms of extraction yield and nature of extractable molecules with a single solvent. However, one of the major problems with this type of solvents is the difficulty to remove them from the extracted mixture due to their low vapor pressure and thus recovering analytes to be used. This review aims to provide an overview of the methods for recovery bioactive molecules from extracts obtained by the application of DESs and NADESs to various food and plant matrices. Methods are critically presented both concerning efficacy and eco-compatibility.

Section snippets

Application of deep eutectic solvent in biomolecules extraction

Since the 1990s, the diffusion of green chemistry and its principles has led to the development of investigations aimed at finding alternatives to common organic solvents employed in many research areas. In recent years, deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) are increasingly applied in the fields of chemical industry and biotechnology. One of the main applications that has required the use of green solvents is the extraction of bioactive molecules from food

Recovery of food bioactive molecules from neoteric solvents extracts

In this section, we present an exhaustive collection of original research manuscripts concerning the method employed for the recovery of food bioactive molecules from neoteric solvents extracts. The bibliographic research has been developed using databases like Scopus (http://www.scopus.com/), PubMed http://www.ncbi.nlm.nih.gov/pubmed) and ISI Web of Knowledge (https://webofknowledge.com/). Table 2 reports used approach together with DES employed for compounds extraction.

The use of macro-porous

Conclusions

In conclusion, the use of DESs has in many cases proved to be a viable alternative to the use of conventional solvents in many applications. The extraction capacity of DES is often superior when compared to that of conventional organic solvents like methanol, ethanol, or aqueous mixtures. This makes the processes of extracting bioactive molecules from plant matrices more eco-friendly by decreasing the environmental impact of process waste. Due to their negligible vapor pressure, their removal

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References (92)

  • M. Vilková et al.

    The role of water in deep eutectic solvent-base extraction

    J. Mol. Liq.

    (2020)
  • Y. Dai et al.

    Tailoring properties of natural deep eutectic solvents with water to facilitate their applications

    Food Chem.

    (2015)
  • M.M. Vuolo et al.

    Chapter 2 - phenolic compounds: structure, classification, and antioxidant power

  • M. Cvjetko Bubalo et al.

    Green extraction of grape skin phenolics by using deep eutectic solvents

    Food Chem.

    (2016)
  • T. Bosiljkov et al.

    Natural deep eutectic solvents and ultrasound-assisted extraction: green approaches for extraction of wine lees anthocyanins

    Food Bioprod. Process.

    (2017)
  • K. Radošević et al.

    Natural deep eutectic solvents as beneficial extractants for enhancement of plant extracts bioactivity

    LMT Food Sci. Technol.

    (2016)
  • A.R. Mansur et al.

    Optimizing the ultrasound-assisted deep eutectic solvent extraction of flavonoids in common buckwheat sprouts

    Food Chem.

    (2019)
  • X. Shang et al.

    Tailor-made natural deep eutectic solvents for green extraction of isoflavones from chickpea (Cicer arietinum L.) sprouts

    Ind. Crop. Prod.

    (2019)
  • L. Zhang et al.

    Optimization of deep eutectic solvent-based ultrasoundassisted extraction of polysaccharides from Dioscorea opposita Thunb

    Int. J. Biol. Macromol.

    (2017)
  • Z. Wang et al.

    Adsorption and desorption characteristics of polyphenols from Eucommia ulmoides Oliv. leaves with macroporous resin and its inhibitory effect on α-amylase and α-glucosidase

    J. Transl. Med.

    (2020)
  • P. Zhao et al.

    Enrichment and purification of total flavonoids from Cortex Juglandis Mandshuricae extracts and their suppressive effect on carbon tetrachloride-induced hepatic injury in Mice

    J. Chromatogr. B Biomed. Appl.

    (2015)
  • Y. Zhang et al.

    Adsorption/desorption characteristics and enrichment of quercetin, luteolin and apigenin from Flos populi using macroporous resin

    Rev. Bras. Farmacogn.

    (2019)
  • J. Cao et al.

    Tailor-made hydrophobic deep eutectic solvents for cleaner extraction of polyprenyl acetates from Ginkgo biloba leaves

    J. Clean. Prod.

    (2017)
  • D.E. Yoo et al.

    Deep eutectic solvent-based valorization of spent coffee grounds

    Food Chem.

    (2018)
  • M. Panić et al.

    Enabling technologies for the extraction of grape-pomace anthocyanins using natural deep eutectic solvents in up-to-half-litre batches extraction of grape-pomace anthocyanins using NADES

    Food Chem.

    (2019)
  • Q. Cao et al.

    Green extraction of six phenolic compounds from rattan (Calamoideae faberii) with deep eutectic solvent by homogenate-assisted vacuum-cavitation method

    Molecules

    (2019)
  • Q. Cui et al.

    Sustainable deep eutectic solvents preparation and their efficiency in extraction and enrichment of main bioactive flavonoids from sea buckthorn leaves

    J. Clean. Prod.

    (2018)
  • G.-H. Xia et al.

    Deep eutectic solvents as green media for flavonoids extraction from the rhizomes of Polygonatum odoratum

    Alex. Eng. J.

    (2021)
  • T. Wang et al.

    Enhanced and green extraction polyphenols and furanocoumarins from Fig (Ficus carica L.) leaves using deep eutectic solvents

    J. Pharm. Biomed.

    (2017)
  • X. Peng et al.

    Green extraction of five target phenolic acids from Lonicerae japonicae Flos with deep eutectic solvent

    Separ. Purif. Technol.

    (2016)
  • X.-L. Qi et al.

    Green and efficient extraction of bioactive flavonoids from Equisetum palustre L. by deep eutectic solvents-based negative pressure cavitation method combined with macroporous resin enrichment

    Ind. Crop. Prod.

    (2015)
  • Z.F. Wei et al.

    Fast and green extraction and separation of main bioactive flavonoids from radix Scutellariae

    Ind. Crop. Prod.

    (2015)
  • M.C. Ali et al.

    Effective extraction of flavonoids from Lycium barbarum L. fruits by deep eutectic solvents-based ultrasound-assisted extraction

    Talanta

    (2019)
  • J.Y. An et al.

    An efficiency strategy for extraction and recovery of ellagic acid from waste chestnut shell and its biological activity evaluation

    Microchem. J.

    (2021)
  • S.S. Patil et al.

    Optimization and kinetic study of ultrasound assisted deep eutectic solvent based extraction: a greener route for extraction of curcuminoids from Curcuma longa

    Ultrason. Sonochem.

    (2021)
  • N.T. Hang et al.

    Green extraction of apigenin and luteolin from celery seed using deep eutectic solvent

    J. Pharm. Biomed.

    (2022)
  • K.M. Jeong et al.

    Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

    J. Chromatogr. A

    (2015)
  • M. Xu et al.

    Polarity-dependent extraction of flavonoids from citrus peel waste using a tailor-made deep eutectic solvent

    Food Chem.

    (2019)
  • X.H. Fan et al.

    Application of green and recyclable menthol-based hydrophobic deep eutectic solvents aqueous for the extraction of main taxanes from Taxus chinensis needles

    J. Mol. Liq.

    (2021)
  • M. Ruesgas-Ramón et al.

    Application of deep eutectic solvents (DES) for phenolic compounds extraction: overview, challenges, and opportunities

    J. Agric. Food Chem.

    (2017)
  • W. Lu et al.

    Choline chloride–based deep eutectic solvents (Ch-DESs) as promising green solvents for phenolic compounds extraction from bioresources: state-of-the-art, prospects, and challenges

    Biomass Conv. Bioref.

    (2020)
  • L. Duan et al.

    Comprehensive evaluation of deep eutectic solvents in extraction of bioactive natural product

    ACS Sustainable Chem. Eng.

    (2016)
  • C. Hongye et al.

    Applications of deep eutectic solvents for hard-to-separate liquid systems

    Separ. Purif. Technol.

    (2021)
  • A.P. Abbott et al.

    Novel solvent properties of choline chloride/urea mixtures

    Chem. Commun.

    (2003)
  • A. Mannu et al.

    Promising technological and industrial applications of deep eutectic systems

    Materials

    (2021)
  • Q. Zhang et al.

    Deep eutectic solvents: syntheses, properties and applications

    Chem. Soc. Rev.

    (2012)

    • Cited by (0)

    View full text
    © 2022 Elsevier B.V. All rights reserved.