The factors affecting purification of concentrated extracts obtained from the aerial parts of two Hypericum species (H. scabrum L. and H. perforatum L.) using 80% EtOH were studied. A five-fold treatment with extraction naphtha followed by six-fold extraction with EtOAc was shown to provide a dry extract with a hypericin content of at least 0.29%. The recommended conditions for obtaining a spray-dried extract of Hypericum were coolant temperature at the inlet, 160 – 180°C; at the outlet, 80 – 90°C; solution delivery rate, 5 L/h; air pressure supplied to the nozzle, 0.15 MPa; and solution concentration, 15%. A unified technology for production of Hypericum dry extract substance from the aerial parts of H. scabrum and H. perforatum was developed and could produce a finished product that met the requirements of foreign pharmacopoeias.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 5, pp. 24 – 29, May, 2023.
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Abdurakhmanov, B.A., Ibragimov, T.F., Sotimov, G.B. et al. Optimal Conditions for Purification and Drying of Dry Extract from the Aerial Part of Hypericum scabrum and Hypericum perforatum. Pharm Chem J 57, 669–674 (2023). https://doi.org/10.1007/s11094-023-02936-8
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DOI: https://doi.org/10.1007/s11094-023-02936-8