Recent advancements in astaxanthin production from microalgae: A review

Anil Kumar Patel; Vaibhav Sunil Tambat; Chiu-Wen Chen; Ajeet Singh Chauhan; Prashant Kumar; Akash Pralhad Vadrale; Chun-Yung Huang; Cheng-Di Dong; Reeta Rani Singhania

doi:10.1016/j.biortech.2022.128030

Recent advancements in astaxanthin production from microalgae: A review

Bioresour Technol. 2022 Nov:364:128030. doi: 10.1016/j.biortech.2022.128030. Epub 2022 Sep 26.

Authors

Anil Kumar Patel¹, Vaibhav Sunil Tambat¹, Chiu-Wen Chen², Ajeet Singh Chauhan¹, Prashant Kumar¹, Akash Pralhad Vadrale³, Chun-Yung Huang⁴, Cheng-Di Dong⁵, Reeta Rani Singhania⁶

Affiliations

¹ Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Centre for Energy and Environmental Sustainability, Lucknow 226 029, Uttar Pradesh, India.
² Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Sustainable Environment Research Centre, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.
³ Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Centre for Energy and Environmental Sustainability, Lucknow 226 029, Uttar Pradesh, India; Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.
⁴ Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan.
⁵ Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan. Electronic address: cddong@nkust.edu.tw.
⁶ Centre for Energy and Environmental Sustainability, Lucknow 226 029, Uttar Pradesh, India; Sustainable Environment Research Centre, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.

PMID: 36174899
DOI: 10.1016/j.biortech.2022.128030

Abstract

Microalgae have emerged as the best source of high-value astaxanthin producers. Algal astaxanthin possesses numerous bioactivities hence the rising demand for several health applications and is broadly used in pharmaceuticals, aquaculture, health foods, cosmetics, etc. Among several low-priced synthetic astaxanthin, natural astaxanthin is still irreplaceable for human consumption and food-additive uses. This review highlights the recent development in production enhancement and cost-effective extraction techniques that may apply to large-scale astaxanthin biorefinery. Primarily, the biosynthetic pathway of astaxanthin is elaborated with the key enzymes involved in the metabolic process. Moreover, discussed the latest astaxanthin enhancement strategies mainly including chemicals as product inducers and byproducts inhibitors. Later, various physical, chemical, and biological cell disruption methods are compared for cell disruption efficiency, and astaxanthin extractability. The aim of this review is to provide a comprehensive review of advancements in astaxanthin research covering scalable upstream and downstream astaxanthin bioproduction aspects.

Keywords: Antioxidant; Astaxanthin; Carotenoid; Microalgae; Pigment.

Publication types

Review

MeSH terms

Aquaculture
Humans
Microalgae* / metabolism
Xanthophylls / metabolism

Substances

astaxanthine
Xanthophylls